Antibodies to opacity proteins (Opa) correlate with a reduced risk of gonococcal salpingitis.
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چکیده
منابع مشابه
Antibodies to opacity proteins (Opa) correlate with a reduced risk of gonococcal salpingitis.
Acute salpingitis complicating cervical gonococcal infection is a significant cause of infertility. Relatively little data are available concerning the pathophysiologic mechanisms of this disease. A cohort of 243 prostitutes residing in Nairobi were followed between March 1985 and April 1988. Gonococcal cultures were performed at each visit, and acute salpingitis was diagnosed clinically. Serum...
متن کاملGonococcal opacity: lectin-like interactions between Opa proteins and lipooligosaccharide.
Previous evidence from our laboratory suggested that the tight intercellular adhesions between the outer membranes of gonococci displaying the opacity colony phenotype occurred because Opa proteins expressed on one gonococcus adhered to the lipooligosaccharide (LOS) of the opposing bacterium (M.S. Blake, p. 51-66, in G. G. Jackson and H. Thomas, ed., The Pathogenesis of Bacterial Infections, 19...
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Editorial The issue of fertility following acute gonococcal salpingitis has been addressed in less than an optimal manner. The often demographic instability of study patients and the need to publish within specific time frames have partially negated the ability to produce long-term studies of the impact of acute gonococcal salpingitis on subsequent fertility. In his study of acute salpingitis, ...
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A series of 25 cases of gonococcal salpingitis were seen in a teaching hospital between October, 1972, and March, 1975. These cases formed 29 per cent of all cases of salpingitis excluding post-abortal cases. The majority were investigated at the bedside by taking films and cultures from the cervix and urethra. The films were stained by Gram's method and specimens for culture were streaked on t...
متن کاملCarcinoembryonic antigen family receptor recognition by gonococcal Opa proteins requires distinct combinations of hypervariable Opa protein domains.
Neisserial Opa proteins function as a family of adhesins that bind heparan sulfate proteoglycan (HSPG) or carcinoembryonic antigen family (CEACAM) receptors on human host cells. In order to define the CEACAM binding domain on Opa proteins, we tested the binding properties of a series of gonococcal (strain MS11) recombinants producing mutant and chimeric Opa proteins with alterations in one or m...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1994
ISSN: 0021-9738
DOI: 10.1172/jci117159